Simon Akerman

Simon Akerman, Ph.D.

Associate Professor, Department of Neural and Pain Sciences

SCHOOL OF DENTISTRY

  • Research interests

    Pathophysiology of primary headaches inc.
    Migraine
    Cluster Headache
    Animal models of primary headaches
    TMDs

  • Research approaches

    Physiological methods in rodents
    In vivo Electrophysiology
    Laser Doppler Flowmetry
    Video Imaging
    Pain behaviors

Publications

1. S Akerman, B Simon and M Romero-Reyes (2017) Vagus nerve stimulation suppresses acute noxious activation of trigeminocervical neurons in animal models of primary headache. Neurobiol Dis. 102:96-104.
2. AP Andreou, PR Holland, S Akerman, O Summ, J Frederik, PJ Goadsby (2016) Transcranial Magnetic Stimulation and Potential Cortical and Trigeminothalamic Mechanisms in Migraine. Brain. 139:2002-2014.
3. S Akerman and PJ Goadsby (2015) Neuronal PAC1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine. Sci Trans Med. 7:308ra157.
4. M Romero-Reyes, V Pardi and S Akerman (2015) A potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist, MK-8825, inhibits responses to nociceptive trigeminal activation: role of CGRP in orofacial pain. Exp Neurol. 271:95-103.
5. S Akerman, PR Holland, MP Lasalandra and PJ Goadsby (2013) Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and 'triptan' receptors: implications in migraine. J Neurosci. 33:14869-14877.