Titles

Co-Chief of Cardiovascular Medicine

Director of Cardiology Research

School Affiliation

School of Medicine

Specialties

• Cardiovascular Genetics
• Inherited Heart Diseases
• Stem Cells

About

615-332-1402 charles.hong@som.umaryland.edu

Charles (Chaz) Hong is a physician-scientist whose research, which functions at the intersection of developmental biology, chemical biology, stem cell biology, and cardiovascular medicine, has led to new biological insights and therapeutic opportunities. Dr. Hong’s work includes innovative chemical genetic studies in zebrafish as well as the use of induced pluripotent stem cell (iPSC) to better understand human heart diseases at the cellular level. His scientific contributions include the first small molecule inhibitor of bone morphogenetic protein (BMP) signaling, which has led directly to a clinical stage therapeutic program for devastating human diseases. Additionally, his small molecules are key components of the “Dual Chemical SMAD Inhibition,” the most widely used strategy to generate neurons and neural organoids from human stem cells. Moreover, his chemical genetic studies elucidated the roles of mitogen-activated kinase in artery-vein specification during development. Finally, he has made important contributions toward the utilization of human iPSC-derived cardiomyocytes (hiPSC-CMs) as an in vitro model for the study of human cardiomyocyte physiology. Dr. Hong edited one of the first books focused on the role of chemical biology in stem cell and regenerative medicine, and a book covering the latest methods and protocols in chemical biology. He serves on editorial boards of number of scientific journals and is inaugural Chief Editor of Frontiers in Drug Discovery overseeing Hematologic and Cardiovascular domains. His ongoing basic investigations include the elucidation of the novel role of centrosome proteins in cardiac structure and function, and therapeutic targeting of a novel pro-oncogenic pathway activated downstream of the Warburg Effect. His clinical expertise is in cardiovascular genetics. Finally, Dr. Hong is a key member of the West Baltimore RICH (Reducing Isolation and Inequities in Cardiovascular Health) Collaborative, an interdisciplinary team of community leaders, churches, local charities, 2 local hospitals, the University of Maryland, and federally qualified health centers to develop sustainable strategies to overcome health disparities in West Baltimore.

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Tagged: The Future of Health Care   Ensuring Access and Equity in Health Care   Research and Innovation   Economic Development  

This information was last updated December 8, 2022.