Titles

Associate Professor of Pharmaceutical Sciences

School Affiliation

School of Pharmacy

Specialties

• Chemical and Biological Discovery

About

pwintrod@rx.umaryland.edu

Dr. Wintrode's research is focused on protein folding and misfolding, and the role of protein dynamics in function and allosteric regulation. His primary research tools are hydrogen/deuterium exchange, radiolytic footprinting, mass spectrometry, molecular dynamics simulation and small angle x-ray scattering. The biological systems he currently focuses on are 1) serpins: a class of metastable protease inhibitors whose unusual biophysical properties render them susceptible to misfolding and polymerization. Serpin misfolding is implicated in a number of inherited diseases including emphysema, thrombosis and early onset dementia. 2) HIV-1 reverse transcriptase: the role of conformational dynamics in inhibition and drug resistance. 3) AAA+ proteases: mechanisms of action and regulation. Additionally, he is part of a collaboration applying novel advanced computational techniques to simulate large conformational changes in all atom detail.

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Tagged: Research and Innovation  

This information was last updated January 5, 2023.